Which of the following describes the signal transduction mechanism for estrogen a steroid hormone

Over the years since 2002 I have had a hip replacement (AVN after hit by a car) several years later the other hip was replaced due to OA, 2012 was my first knee replacement and 2014 my second (both done at NE Baptist hospital in Boston) Significant pain pre and post replacements. Relief was obtained with Vioxx,
(until off the market) then ibuprofen, tylenol PM at night. Opioids prescribed post op but not used after 2-3 weeks home. I was never told not to take ansaids nor that my healing was less then what was expected. I returned to my job as homecare case manager after all surgeries within 12 weeks, lots of physical activity required. Always x strength tylenol suggested (never effective for me)
! month ago I underwent back surgery . Discharged on neurontin and roxicet and of course x strength tylenol. Pain has been hard to control (developed sciatic pain especially at night) Calls to MD resulted in increased dose of both neurontin and opioids. Also using ice and topical ointments with some short term decrease in pain. While using cane for balance I injured my rotator cuff L shouider. I was told by my surgeon absolutely no ansaids. Finding this incredibly difficult and started looking for articles and information on this as it has such an impact on pain management and recovery. Ambulation and sleep are
difficult as are ability to stay positive. I found this article helpful and hope there is indeed more research going on. Thank you for this site Pam

For over 50,000 subreddits that span a huge range of topics, it gets a bit more complicated. Instead of characterizing all of them in terms of just two subreddits — like r/Outdoors and r/nutrition above — we ranked all of the subreddits by the number of unique commenters and then pulled out the 2,133 subreddits whose unique commenter rank was between 200 and 2,201 (there are some ties). We used this subset of subreddits to characterize all active subreddits. 5 We then combined all the resulting subreddit vectors into a big matrix with 50,323 rows and 2,133 columns and converted the raw co-occurrences to positive pointwise mutual information values . 6 Similarity between subreddits is based on the cosine similarity of their vectors — a measure of the angle between them. To perform subreddit algebra, subreddit vectors are added and subtracted using standard linear algebra, and then the cosine similarities are calculated to rank subreddits by their similarity to the combination.

Better and so informative content but I have some questions. First while targeting sometimes I assess the broader audience gives better results than specified one and sometimes this proves totally wrong and need to be more specified targeting. What is this and how I can overcome on this?
Secondly how we can target the perfect audience like behaviour, interests?
Is the way of tracking via facebook pixels is accurate? How much if yes? I tried to use but got it's just like an estimation nothing else or might be I'm wrong somewhere while tracking.
And presently I'm experimenting either placing an ad on multiple platforms like Instagram, mobile news feed, the desktop news feed is better or placing in different places with different versions of the same ad.
Thanks in advance.

Which of the following describes the signal transduction mechanism for estrogen a steroid hormone

which of the following describes the signal transduction mechanism for estrogen a steroid hormone

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