Dry, chapped, and itchy skin on the hands that doesn’t improve with moisturizer may be a sign of hand eczema. Symptoms can include red, itchy, inflamed skin with blistering that can lead to oozing, crusting, and cracking. People who have their hands in water all day or work closely with irritants such as detergents or solvents are more likely to develop this type of eczema. If you had atopic dermatitis as a child, you may also have a higher risk of developing hand eczema. Applying a cream after washing hands or wearing gloves may help protect hands from future flare-ups.