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The existing data show that the popular supplements St. John's wort, valerian, and omega-3 fatty acids have little therapeutic value for anxiety disorders, and their use should be discouraged in favor of more effective treatments. In addition, many preparationsthat might be used by patients to reduce anxiety lack evidence of effectiveness with anxiety disorders. The availability of natural treatments that are supported by clinical evidence and the recognition of those that are not will help physicians collaborate with patients using or seeking natural remedies to maximize the potential for benefit and minimize the potential for harm.