Because steroids are lipophilic, they diffuse easily through the cell membranes, and therefore have a very large distribution volume. In their target tissues, steroids are concentrated by an uptake mechanism which relies on their binding to intracellular proteins (or " receptors ", see below). High concentration of steroids are also found in adipose tissue, although this is not a target for hormone action. In the human male, adipose tissue contains aromatase activity, and seems to be the main source of androgen-derived estrogens found in the circulation. But most of the peripheral metabolism occurs in the liver and to some extent in the kidneys, which are the major sites of hormone inactivation and elimination, or catabolism (see below).
Zinc is a critical mineral that balances copper. Zinc is closely related to testosterone in men and progesterone in women. Zinc is one mineral in particular that is deficient in many people's diets. It is found abundantly in organ meats, red meat and in smaller amounts in pumpkin seeds. But there are not too many other places to get adequate zinc into your diet. On the flip side, there are many exogenous sources of estrogen, including xenoestrogens, which are found in chemicals, fertilizers, petroleum products. Xenoestrogens are abundant in the environment, and virtually all people are exposed to them in high amounts.