Side effect of steroids in children

Growth and function of the prostate depend on the endocrine. The biggest impact is especially testosterone and estrogen. Taking steroids is not without effect on the endocrine. This leads to an increased secretion of DHT (dihydrotestosterone) – a hormone which binds to receptors located in the cells of the prostate gland. This has the effect of their strong growth and division. While under normal conditions, this process is completely controlled, whereas in the case of taking steroids not necessarily. Therefore it is easy for prostate cancer.

Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile . [43] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception . [44] In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [45] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [46] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

  1. Male patients with carcinoma of the breast , or with known or suspected carcinoma of the prostate .
  2. Carcinoma of the breast in females with hypercalcemia ; androgenic anabolic steroids may stimulate osteolytic resorption of bone .
  3. Nephrosis or the nephrotic phase of nephritis .
  4. WINSTROL (anabolic steroids) can cause fetal harm when administered to a pregnant woman.
WINSTROL (anabolic steroids) is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy , or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus .

Side effect of steroids in children

side effect of steroids in children

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