Progestogenic steroids

Pharmacom Labs PHARMA Nan D300 is presented in a 10ml vial and reportedly contains 300 milligrams of nandrolone decanoate per milliliter according to the label and packaging. Samples of this product were purchased from a European-based authorized reseller and internet source between the dates of April 10, 2015 and May 10, 2015. The samples were forwarded and received by the analytical laboratory Simec AG for HPLC-UV testing on May 19, 2015. The quantitative dosage testing report was completed on June 2, 2015. The “quality code” listed on the product was “zpgtek35de”. The quality code was successfully used to authenticate/verify the product on /code.

Conclusion
Healthcare professionals should be aware that up to 60% of women discontinue using Mirena within five years due to unscheduled bleeding, pain and/or progestogenic adverse effects. The notion that Mirena works as entirely a local source of LNG should be revised since the serum LNG in users may be equivalent to that of two LNG-containing progestogen only pill taken daily on a continuous basis, and the tissue concentrations of LNG, other than the endometrium, users may be equivalent to that of six LNG-containing progestogen only pill. Mirena seems to delay rather than replace hysterectomy, and it may best suit women who are approaching the age of menopause. The high discontinuation and adverse effects rates should be readily available to women to be able to make an informed choice as regards using Mirena.

In a study of 1,685 patients treated with CPA, elevated liver enzymes were seen in 10% of patients at a dosage of 50 mg/day and in 20% of patients at a dosage of greater than 100 mg/day. [50] A study of 2,506 patients given 18–136 mg/day for less than 48 months per patient reported a rate of %. [51] [52] In a trial of 89 prostate cancer patients who received high-dose CPA for 4 years, there were elevated liver enzymes in % of the patients. [52] Yet another study of 105 patients found a hepatotoxicity rate of %, with serious hepatic injury occurring in %. [52] In 2002, it was reported that there were 18 case reports of CPA-associated hepatitis in the medical literature, with 6 of the cases resulting in death. [50] In addition, a review article cited a report of 96 instances of hepatotoxicity that were attributed to CPA, and 33 of these instances resulted in death. [50] Moreover, a 2014 review found that 15 cases specifically of CPA-induced fulminant (sudden-onset and severe) liver failure had been reported to date, with only one of these cases not resulting in death. [52] As such, the prognosis of CPA-induced liver failure is death. [52]

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. [45]

Progestogenic steroids

progestogenic steroids

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. [45]

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