Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile .  The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception .  In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.  The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field.  The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.
Each user experiences their own unique feelings when using steroids and coming off the drug. When someone chooses to stop using they can experience a variety of withdrawal symptoms linked to addiction. Symptoms can include mood swings, fatigue, restlessness, loss of appetite, insomnia, reduced sex drive, the desire to take more steroids, and depression. Evidence for steroid addiction is certainly not as strong as it is for other drugs like cocaine or heroin. Though it is clear that people develop a tolerance and dependence on them and willingly experience negative consequences when using steroids - both of which are signs for drug dependence.
The Oral Steroids Winstrol & Anavar:The Oral Steroids Winstrol & Anavar:The Oral Steroids Winstrol & Anavar:vWhile both of these oral steroids can be used for both bulking and cutting, most male anabolic steroid users will be better served using them as a part of a leaning or cutting cycle. Neither drug will produce abundant gains in size but they serve as a well refined tool in terms of holding on to strength as well as helping produce a harder physique. As it pertains to Winstrol, some may find a more suitable use during an off-season period in conjunction with other anabolic steroids; an increase in strength is always a welcomed attribute but do not expect to see the scale move upward in serious fashion due to Winstrol use. The same cannot be said of Anavar; most men will find Anavar suited only for cutting cycles but be aware, there are far better suited anabolic steroids we can use for this purpose but don’t be fooled, Anavar does have a place in both bulking and cutting cycles. Anavar is not only one of the best oral steroids for females it is one of the best anabolic steroids for female’s period. Due to its very mild effects Anavar is one of the safest anabolics a woman can use and in general at a very low dose and still see fantastic results. Anavar can be successfully used by women during both bulking and cutting cycles quite well.