Ninety-two (92) AEs were noted in CS versus 31 in CO and included: fracture (CS:21 versus CO:8), serious infections (CS:14 versus CO:4), gastrointestinal (GI) bleed or ulcer (CS:11 versus CO:4), and cataracts (CS:17 versus CO:5). At time of first AE, CS prednisone average dose was +/- mg with a duration of +/- years. Stepwise multiple logistic regression analysis was used to create a model which included all clinically relevant variables and all parameters significantly different at the cohort inception. Prednisone average dose of greater than 10 to less than or equal to 15 mg/d correlated most strongly with the development of an AE (Odds Ratio (OR) = , 95% Confidence Interval (CI) , 220). Average prednisone 5 to 10 mg (OR = , 95% CI , ), RA nodules (OR = , 95% CI , ), and bony erosions (OR = , 95% CI , ) also entered the final model. Kaplan Meier survival curves for the development of the first AE showed a dose-response relationship between prednisone and AE occurrence, independent of rheumatoid nodules. Subset analyses utilized a nested case control design for the development of three serious AEs: fractures, serious infections, and GI events. These analyses revealed possible relationships between prednisone use and the development of each specific AE (prednisone use OR: fracture , 95% CI , ; infection , 95% CI , ; and GI event , 95% CI , ).
Hey, great list!
I don’t use them personally, but I train with a few women who do. I’ve noticed some of the side effects and they’ve mentioned it too.
But I didn’t know what to look for and how many alternatives there were – so while I’ll probably still choose not to use any (my goals are just to stay active), I’ll pass this along to my friends who want different results than I do. Maybe it’ll help them make some good choices, or to switch to something with fewer (or no) side effects.
Just as taking prednisone can cause side effects, reducing the dose may cause problems as well. Prednisone is not addicting like a narcotic, but many patients experience withdrawal symptoms as the dose is reduced. These often include muscle soreness, joint pain, fatigue, and depression. Know that these effects are also temporary and worth bearing to allow a cutback in your dose. If you experience any unusual symptoms as your prednisone dose is reduced, contact your doctor. It may be necessary to temporarily increase your steroid dose until you are feeling better and then taper the dose more slowly.