Eicosanoids are derived from steroids true or false

There are at least four leukotriene receptors. Two receptors have been characterized that bind LTB 4 called BLT 1 and BLT 2 and two receptors that bind the peptidoleukotrienes (cysteinyl leukotrienes) called CysLT1 and CysLT2. The BLT 1 receptor is encoded by the LTB4R gene located on chromosome –q12 and is composed of 3 exons that generates two variant mRNAs that both encode a protein of 352 amino acids. The BLT 2 receptor is encoded by the LTB4R2 gene which is located on chromosome 14q12 and is composed of 2 exons generate two variant mRNAs that both encode a protein of 358 amino acids. The CysLT1 receptor is encoded by the CYSLTR1 gene located on the X chromosome (–) and is composed of 5 exons that generates four variant mRNAs, each of which encode the same 337 amino acid protein. The CysLT2 receptor is encoded by the CYSLTR2 gene located on chromosome and contains a single exon encoding a protein of 346 amino acids.

The basic structure of phospolipids is very similar to that of the triglycerides except that C–3 ( sn 3)of the glycerol backbone is esterified to phosphoric acid. The building block of the phospholipids is phosphatidic acid. Substitutions that can be added to phosphatidic acid include ethanolamine (phosphatidylethanolamines, PE), choline (phosphatidylcholines, PC: also called lecithins), serine (phosphatidylserines, PS), glycerol (phosphatidylglycerols, PG), myo -inositol (phosphatidylinositols, PI: these compounds can have a variety in the numbers of inositol alcohols that are phosphorylated generating polyphosphatidylinositols), and phosphatidylglycerol (diphosphatidylglycerols, DPG; more commonly known as cardiolipins). See the Lipid Synthesis page for images of the various phospholipids.

SUMMARY AND SUGGESTIONS There is no doubt that inhibiting eicosanoid synthesis by modern drugs therapies is effective for many people in reducing the inflammation and the accompanying pain of many diseases, particularly arthritis. It has been shown that regular consumption of aspirin, even in small doses of about 80 mg/day, reduces risk of heart attack and colon cancer, and this effect appears to be mediated, at least in part, by inhibiting eicosanoids. For those suffering from serious diseases, many wish to avoid using the standard drugs, or avoid using them frequently, due to experience of side effects or concerns about side effects. Prolonged use of corticosteroid drugs and NSAIDS has been linked to serious reactions in some individuals. In order to take reasonable steps to minimize the symptoms of these diseases through means other than relying on the drugs, it is important to understand the process by which the inflammation and other disease manifestations (., platelet sticking, bronchiospasms) occur.

The enzymes 15-lipoxygenase -1 (15-LO-1 or ALOX15 ) and 15-lipoxygenase-2 (15-LO-2, ALOX15B ) metabolize arachidonic acid to the S stereoisomer of 15-Hydroperoxyeicosatetraenoic acid (15(S)-HPETE) which is rapidly reduced by cellular peroxidases to the S stereoisomer of 15-Hydroxyicosatetraenoic acid (15(S)-HETE). [44] [45] The 15-lipoxygenases (particularly ALOX15) may also act in series with 5-lipoxygenase, 12-lipoxygenase, or aspirin-treated COX2 to form the lipoxins and epi-lipoxins or with P450 oxygenases or aspirin-treated COX2 to form Resolvin E3 (see Specialized pro-resolving mediators#EPA-derived resolvins .

Eicosanoids are derived from steroids true or false

eicosanoids are derived from steroids true or false

The enzymes 15-lipoxygenase -1 (15-LO-1 or ALOX15 ) and 15-lipoxygenase-2 (15-LO-2, ALOX15B ) metabolize arachidonic acid to the S stereoisomer of 15-Hydroperoxyeicosatetraenoic acid (15(S)-HPETE) which is rapidly reduced by cellular peroxidases to the S stereoisomer of 15-Hydroxyicosatetraenoic acid (15(S)-HETE). [44] [45] The 15-lipoxygenases (particularly ALOX15) may also act in series with 5-lipoxygenase, 12-lipoxygenase, or aspirin-treated COX2 to form the lipoxins and epi-lipoxins or with P450 oxygenases or aspirin-treated COX2 to form Resolvin E3 (see Specialized pro-resolving mediators#EPA-derived resolvins .

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